Recombinant DNA: Genes and Genomes by James D. Watson; Richard M. Myers; Amy A. Caudy; Jan A. Witkowski - Third Edition, 2007 from Macmillan Student Store

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Recombinant DNA: Genes and Genomes

Third  Edition©2007 James D. Watson; Richard M. Myers; Amy A. Caudy; Jan A. Witkowski

About

Recombinant DNA, Third Edition, is an essential text for undergraduate, graduate, and professional courses in Genomics, Cell and Molecular Biology, Recombinant DNA, Genetic Engineering, Human Genetics, Biotechnology, and Bioinformatics.
 
The Third Edition of this landmark text offers an authoritative, accessible, and engaging introduction to modern, genome-centered biology from its foremost practitioners.  The new edition explores core concepts in molecular biology in a contemporary inquiry-based context, building its coverage around the most relevant and exciting examples of current research and landmark experiments that redefined our understanding of DNA.  As a result, students learn how working scientists make real high-impact discoveries.
 
The first chapters provide an introduction to the fundamental concepts of genetics and genomics, an inside look at the Human Genome Project, bioinformatic and experimental techniques for large-scale genomic studies, and a survey of epigenetics and RNA interference. The final chapters cover the quest to identify disease-causing genes, the genetic basis of cancer, and DNA fingerprinting and forensics. In these chapters the authors provide examples of practical applications in human medicine, and discuss the future of human genetics and genomics projects.

Table of Contents

FOUNDATIONS OF DNA
1. DNA Is the Primary Genetic Material
2. Information Flow from DNA to Protein
3. Control of Gene Expression
4. Basic Tools of Recombinant DNA
5. Fundamental Features of Eukaryotic Genes
6. A New Toolbox for Recombinant DNA
7. Mobile DNA Sequences in the Genome
8. Epigenetic Modifications of the Genome
9. RNA Interference Regulates the Genome 
     
FOUNDATIONS OF GENOMICS
10. Fundamentals of Whole-Genome Sequencing         
11. How the Human Genome was Sequenced  
 
ANALYZING GENOMES
12. Comparing and Analyzing Genomes           
13. From Genome Sequence to Gene Function
         
HUMAN GENOMICS
14. Finding Human Disease Genes
15. Understanding the Genetic Basis of Cancer
16. DNA Fingerprinting and Forensics

James D. Watson

Richard M. Myers

Amy A. Caudy

Amy A. Caudy is the Lewis-Stiger Fellow at the Lewis-Stiger Institute for Integrative Genomics at Princeton University.  Her research focuses on the function and replication of mitochondria in yeast and mammals. Combining methods from genomics, genetics, and biochemistry, Caudy's laboratory seeks to understand the regulation of mitochondrial levels, identifying new genes required for mitochondrial organization and biogenesis using screens as well as computational predictions of gene function.

Jan A. Witkowski

Jan A. Witkowski is Executive Director of the Banbury Center and Professor in the Watson School of Biological Sciences at Cold Spring Harbor Laboratory.