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Molecular Biology by Michael M. Cox; Jennifer Doudna; Michael O'Donnell - Second Edition, 2015 from Macmillan Student Store
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Molecular Biology

Second  Edition|©2015  Michael M. Cox; Jennifer Doudna; Michael O'Donnell

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  • About
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  • Contents
  • Authors

About

Learn how science is done and get excited about scientific discovery. Molecular Biology takes you through the fundamental concepts of science by sharing the work of researchers who have shaped, and who continue to shape the field today.

Digital Options

E-book

Read online (or offline) with all the highlighting and notetaking tools you need to be successful in this course.

Learn More

Launchpad

Get the e-book, do assignments, take quizzes, prepare for exams and more, to help you achieve success in class.

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Contents

Table of Contents

I. Foundations

1. Evolution, Science, and Molecular Biology

2. DNA: The Repository of Biological Information

3. Chemical Basis of Information Molecules

4. Protein Structure

5. Protein Function

II. Nucleic Acid Structure and Methods

6. DNA and RNA Structure

7. Studying Genes

8. Genomes, Transcriptomes, and Proteomes

9. Topology: Functional Deformations of DNA

10. Nucleosomes, Chromatin, and Chromosome Structure

III. Information Transfer

11. DNA Replication

12. DNA Mutation and Repair

13. Recombinational DNA Repair and Homologous Recombination

14. Site-Specific Recombination and Transposition

15. Transcription: DNA-Dependent Synthesis of RNA

16. RNA Processing

17. The Genetic Code

18. Protein Synthesis

IV. Regulation

19. Regulating the Flow of Information

20. The Regulation of Gene Expression in Bacteria

21. The Transcriptional Regulation of Gene Expression in Eukaryotes

22. The Posttranscriptional Regulation of Gene Expression in Eukaryotes

Appendix: Model Organisms

Glossary

Solutions to Problems

Index

 

Authors

Michael M. Cox

Michael M. Cox was born in Wilmington, Delaware. In his firstbiochemistry course, the first edition of Lehninger’s Biochemistry was amajor influence in refocusing his fascination with biology and inspiringhim to pursue a career in biochemistry. After graduate work at BrandeisUniversity with William P. Jencks and postdoctoral work at Stanford with I.Robert Lehman, he moved to the University of Wisconsin–Madison in 1983. Hebecame a full professor of Biochemistry in 1992. Mike Cox has coordinatedan active research team at Wisconsin investigating the function andmechanism of enzymes that act at the interface of DNA replication, repair, and recombination. That work has resulted in over 200 publications to date.For more than three decades, Cox has taught introductory biochemistry toundergraduates and has lectured in a variety of graduate courses. Heorganized a course on professional responsibility for first-year graduatestudents and established a systematic program to draw talented biochemistryundergraduates into the laboratory at an early stage of their collegecareer. He has received multiple awards for both his teaching and hisresearch, including the Eli Lilly Award in Biological Chemistry, electionas a AAAS fellow, and the UW Regents Teaching Excellence Award. Cox’shobbies include turning 18 acres of Wisconsin farmland into an arboretum,wine collecting, and assisting in the design of laboratory buildings.


Jennifer Doudna

Jennifer A. Doudna grew up on the Big Island of Hawaii, where she became interested in chemistry and biochemistry during her high school years. She is currently Professor of Molecular and Cell Biology and Professor of Chemistry at the University of California, Berkeley and an Investigator of the Howard Hughes Medical Institute. She received her B.A. in biochemistry from Pomona College and her Ph.D. from Harvard University, working in the laboratory of Jack Szostak, with whom she also did postdoctoral research. She next went to the University of Colorado as a Lucille P. Markey scholar and postdoctoral fellow with Thomas Cech. Doudna has also been a Donaghue Young Investigator, a Searle scholar, and a Beckman Young Investigator, and she is a former fellow of the David and Lucile Packard Foundation. She has received numerous awards for her research on RNA and RNA-protein structure and function, including the Johnson Foundation Prize for innovative research, the National Academy of Sciences Award for initiatives in research, the Alan T. Waterman Award from the National Science Foundation, and the Eli Lilly Award in Biological Chemistry from the American Chemical Society. She is a member of the Scientific Advisory Board of the David and Lucile Packard Foundation and a Trustee of Pomona College. Doudna is a member of the National Academy of Sciences and the American Academy of Arts and Sciences. She is also a Fellow of the American Association for the Advancement of Science. Jennifer is the recipient of the 2020 Nobel Prize for chemistry for herresearch on CRISPR gene editing.


Michael O'Donnell

Michael O’Donnell received his Ph.D. at the University of Michigan, where he worked under Charles Williams Jr. on electron transfer in the flavoprotein thioredoxin reductase. He performed postdoctoral work on E. coli replication with Arthur Kornberg and then on herpes simplex virus replication with I. Robert Lehman, both in the biochemistry department at Stanford University. O’Donnell then became a member of the faculty of Weill Cornell Medical College in 1986 and an investigator at the Howard Hughes Medical Institute in 1992 before moving to The Rockefeller University in 1996. O’Donnell is a member of the National Academy of Sciences.


Learn how science is done and get excited about scientific discovery. Molecular Biology takes you through the fundamental concepts of science by sharing the work of researchers who have shaped, and who continue to shape the field today.

E-book

Read online (or offline) with all the highlighting and notetaking tools you need to be successful in this course.

Learn More

Launchpad

Get the e-book, do assignments, take quizzes, prepare for exams and more, to help you achieve success in class.

Learn More

Table of Contents

I. Foundations

1. Evolution, Science, and Molecular Biology

2. DNA: The Repository of Biological Information

3. Chemical Basis of Information Molecules

4. Protein Structure

5. Protein Function

II. Nucleic Acid Structure and Methods

6. DNA and RNA Structure

7. Studying Genes

8. Genomes, Transcriptomes, and Proteomes

9. Topology: Functional Deformations of DNA

10. Nucleosomes, Chromatin, and Chromosome Structure

III. Information Transfer

11. DNA Replication

12. DNA Mutation and Repair

13. Recombinational DNA Repair and Homologous Recombination

14. Site-Specific Recombination and Transposition

15. Transcription: DNA-Dependent Synthesis of RNA

16. RNA Processing

17. The Genetic Code

18. Protein Synthesis

IV. Regulation

19. Regulating the Flow of Information

20. The Regulation of Gene Expression in Bacteria

21. The Transcriptional Regulation of Gene Expression in Eukaryotes

22. The Posttranscriptional Regulation of Gene Expression in Eukaryotes

Appendix: Model Organisms

Glossary

Solutions to Problems

Index

 

Michael M. Cox

Michael M. Cox was born in Wilmington, Delaware. In his firstbiochemistry course, the first edition of Lehninger’s Biochemistry was amajor influence in refocusing his fascination with biology and inspiringhim to pursue a career in biochemistry. After graduate work at BrandeisUniversity with William P. Jencks and postdoctoral work at Stanford with I.Robert Lehman, he moved to the University of Wisconsin–Madison in 1983. Hebecame a full professor of Biochemistry in 1992. Mike Cox has coordinatedan active research team at Wisconsin investigating the function andmechanism of enzymes that act at the interface of DNA replication, repair, and recombination. That work has resulted in over 200 publications to date.For more than three decades, Cox has taught introductory biochemistry toundergraduates and has lectured in a variety of graduate courses. Heorganized a course on professional responsibility for first-year graduatestudents and established a systematic program to draw talented biochemistryundergraduates into the laboratory at an early stage of their collegecareer. He has received multiple awards for both his teaching and hisresearch, including the Eli Lilly Award in Biological Chemistry, electionas a AAAS fellow, and the UW Regents Teaching Excellence Award. Cox’shobbies include turning 18 acres of Wisconsin farmland into an arboretum,wine collecting, and assisting in the design of laboratory buildings.


Jennifer Doudna

Jennifer A. Doudna grew up on the Big Island of Hawaii, where she became interested in chemistry and biochemistry during her high school years. She is currently Professor of Molecular and Cell Biology and Professor of Chemistry at the University of California, Berkeley and an Investigator of the Howard Hughes Medical Institute. She received her B.A. in biochemistry from Pomona College and her Ph.D. from Harvard University, working in the laboratory of Jack Szostak, with whom she also did postdoctoral research. She next went to the University of Colorado as a Lucille P. Markey scholar and postdoctoral fellow with Thomas Cech. Doudna has also been a Donaghue Young Investigator, a Searle scholar, and a Beckman Young Investigator, and she is a former fellow of the David and Lucile Packard Foundation. She has received numerous awards for her research on RNA and RNA-protein structure and function, including the Johnson Foundation Prize for innovative research, the National Academy of Sciences Award for initiatives in research, the Alan T. Waterman Award from the National Science Foundation, and the Eli Lilly Award in Biological Chemistry from the American Chemical Society. She is a member of the Scientific Advisory Board of the David and Lucile Packard Foundation and a Trustee of Pomona College. Doudna is a member of the National Academy of Sciences and the American Academy of Arts and Sciences. She is also a Fellow of the American Association for the Advancement of Science. Jennifer is the recipient of the 2020 Nobel Prize for chemistry for herresearch on CRISPR gene editing.


Michael O'Donnell

Michael O’Donnell received his Ph.D. at the University of Michigan, where he worked under Charles Williams Jr. on electron transfer in the flavoprotein thioredoxin reductase. He performed postdoctoral work on E. coli replication with Arthur Kornberg and then on herpes simplex virus replication with I. Robert Lehman, both in the biochemistry department at Stanford University. O’Donnell then became a member of the faculty of Weill Cornell Medical College in 1986 and an investigator at the Howard Hughes Medical Institute in 1992 before moving to The Rockefeller University in 1996. O’Donnell is a member of the National Academy of Sciences.


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